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3-Amino-1-propanesulfonic acid
Base Information
- Chemical Name:3-Amino-1-propanesulfonic acid
- CAS No.:3687-18-1
Good factory exports good 3-Amino-1-propanesulfonic acid 3687-18-1
- Molecular Formula:C3H9NO3S
- Molecular Weight:139.175
- Appearance/Colour:White powder
- Melting Point:293 °C (dec.)(lit.)
- Refractive Index:1.5130 (estimate)
- PKA:1.06±0.50(Predicted)
- PSA：88.77000
- Density:1.387 g/cm3
- LogP:1.00410
3-Amino-1-propanesulfonic acid(Cas 3687-18-1) Usage
|
Biological Activity |
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo . |
InChI:InChI=1/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
3687-18-1 Relevant articles
Preparation method of 3-aminopropanesulfonic acid
-
Paragraph 0037-0059, (2021/05/01)
The invention provides a synthesis metho...
Preparation method of nitrobenzoate
-
Paragraph 0041-0045; 0056; 0057, (2020/07/15)
The invention relates to the field of pe...
Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors
Geng, Aixin,Cui, Hao,Zhang, Liyuan,Chen, Xin,Li, Hongmei,Lu, Tao,Zhu, Yong
supporting information, p. 1605 - 1608 (2019/05/02)
Histone deacetylase (HDAC)inhibitors as ...
Tuning a robust system: N,O zinc guanidine catalysts for the ROP of lactide
Sch?fer, Pascal M.,McKeown, Paul,Fuchs, Martin,Rittinghaus, Ruth D.,Hermann, Alina,Henkel, Johanna,Seidel, Sebastian,Roitzheim, Christoph,Ksiazkiewicz, Agnieszka N.,Hoffmann, Alexander,Pich, Andrij,Jones, Matthew D.,Herres-Pawlis, Sonja
, p. 6071 - 6082 (2019/05/17)
Non-toxic, highly active and robust comp...
3687-18-1 Process route
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-
156-87-6
propan-1-ol-3-amine
-
-
3687-18-1
Homotaurin
| Conditions | Yield |
|---|---|
|
propan-1-ol-3-amine;
With
sulfur trioxide; sodium iodide;
at 110 ℃;
for 0.75h;
under 60006 Torr;
Inert atmosphere;
With
hydrogenchloride;
In
water;
at 20 ℃;
pH=6;
Reagent/catalyst;
Temperature;
Pressure;
|
96.5% |
-
-
107-57-3
3-chloro-2-hydroxypropane-1-sulfonic acid
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-
3687-18-1
Homotaurin
| Conditions | Yield |
|---|---|
|
In
water; ethylenediamine;
|
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-
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-
116112-33-5
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-
160427-74-7
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-
886540-57-4
C11H11N3O5S2