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3-Thiopheneacetic acid
Base Information
- Chemical Name: 3-Thiopheneacetic acid
- CAS No.: 6964-21-2
Good factory supply good 3-Thiopheneacetic acid 6964-21-2
- Molecular Formula: C6H6O2S
- Molecular Weight: 142.178
- Appearance/Colour: white to light yellow crystal powder
- Vapor Pressure: 0.00265mmHg at 25°C
- Melting Point: 73-76 °C(lit.)
- Refractive Index: 1.5300 (estimate)
- Boiling Point: 274.3 °C at 760 mmHg
- PKA: 4.25±0.10(Predicted)
- Flash Point: 119.7 °C
- PSA： 65.54000
- Density: 1.336 g/cm3
- LogP: 1.37520
3-Thiopheneacetic acid(Cas 6964-21-2) Usage
|
Purification Methods |
Crystallise the acid from ligroin or H2O. [Beilstein 18 III/IV 4066.] |
|
General Description |
3-Thiopheneacetic acid acts as monocarboxylate ligand and forms oxo-carboxylate bridged digadolinium(III) complexes. Electrochemical oxidation of 3-thiopheneacetic acid in dry acetonitrile leads to the formation of a conducting polymeric film of poly (3-thiopheneacetic acid). |
InChI:InChI=1/C6H6O2S/c7-6(8)3-5-1-2-9-4-5/h1-2,4H,3H2,(H,7,8)/p-1
6964-21-2 Relevant articles
Desulfonylative Electrocarboxylation with Carbon Dioxide
Zhong, Jun-Song,Yang, Zi-Xin,Ding, Cheng-Lin,Huang, Ya-Feng,Zhao, Yi,Yan, Hong,Ye, Ke-Yin
supporting information, p. 16162 - 16170 (2021/09/02)
Electrocarboxylation of organic halides ...
Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2
Yan, Si-Shun,Zhu, Lei,Ye, Jian-Heng,Zhang, Zhen,Huang, He,Zeng, Huiying,Li, Chao-Jun,Lan, Yu,Yu, Da-Gang
, p. 4873 - 4878 (2018/06/07)
The first ruthenium-catalyzed umpolung c...
Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents
Young, Jonathan R.,Huang, Song X.,Chen, Irene,Walsh, Thomas F.,DeVita, Robert J.,Wyvratt Jr., Matthew J.,Goulet, Mark T.,Ren, Ning,Lo, Jane,Yang, Yi Tien,Yudkovitz, Joel B.,Cheng, Kang,Smith, Roy G.
, p. 1723 - 1727 (2007/10/03)
A series of 3-arylquinolones was prepare...
Synthesis of phenylacetic acids under rhodium-catalyzed carbonylation conditions
Giroux,Nadeau,Han
, p. 7601 - 7604 (2007/10/03)
Benzyl halides are efficiently carbonyla...
6964-21-2 Process route
-
-
71637-34-8
3-hydroxymethyl-thiophene
-
-
201230-82-2
carbon monoxide
-
-
6964-21-2
thiophen-3-yl-acetic acid
-
-
616-44-4,84928-92-7
3-Methylthiophene
| Conditions | Yield |
|---|---|
|
With
hydrogen iodide;
tetrakis(triphenylphosphine) palladium(0);
In
acetone;
at 90 ℃;
for 42h;
under 68400 Torr;
|
34%
11% |
|
With
tetrakis(triphenylphosphine) palladium(0); hydrogen iodide;
In
acetone;
at 90 ℃;
for 42h;
under 68400 Torr;
|
34 % Spectr.
11 % Spectr. |
-
-
34846-44-1
3-Bromomethylthiophene
-
-
201230-82-2
carbon monoxide
-
-
6964-21-2
thiophen-3-yl-acetic acid
| Conditions | Yield |
|---|---|
|
3-Bromomethylthiophene; carbon monoxide;
With
chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide;
at 80 ℃;
for 18h;
under 760 Torr;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
|
85%
|
6964-21-2 Upstream products
-
34846-44-1
3-Bromomethylthiophene
-
143-33-9
sodium cyanide
-
13781-66-3
2-(thiophene-3-yl) acetamide
-
37784-63-7
ethyl-3 thiophene acetate
6964-21-2 Downstream products
-
80154-20-7
N-(3-thienyl-β-ethyl)-3-thienylacetamide
-
58414-52-1
thiophen-3-yl-acetic acid methyl ester
-
70474-57-6
N-(4-benzyloxy-3-methoxy-β-phenethyl)-3-thienylacetamide
-
127035-90-9
2,6-Dimethyl-4-((E)-2-thiophen-3-yl-vinyl)-phenol
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